Acetophenone → 1-Phenylethanol, (R)-

Participants

Reaction Steps

The acetophenone was added to the catalyst solution. The mixture was stirred at ambient temperature for 1 h. Sodium 2-propoxide (0.25 ml of freshly prepared 0.1M solution in 2-propanol) was added. The mixture was stirred for 2 h and sampled; 57% of the acetophenone had reacted to give (R)-1-phenylethanol of 79% ee. The turnover number, integrated over 1 h, was 241 h−1.

Provenance & Evidence