Acetophenone → 1-Phenylethanol, (R)-

Participants

Reaction Conditions

Reaction Steps

Acetophenone (5 ml, 42.9 mmol) was added to a dry Schlenck flask containing 250 ml 2-propanol. Then a portion (2 ml) of the catalyst solution was added followed by sodium 2-propoxide solution (0.3 ml of 0.1 M solution in 2-propanol). The mixture was stirred at 18° C. under vacuum (28 mmHg) for 5 h. This gave (R)-1-phenylethanol Yield 74%, ee 86.8%. The initial turnover number, integrated over 1 h, was 1947 h−1.

Provenance & Evidence