HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → (4-Fluoro-2-nitro-5-pyrrolidin-1-yl-phenyl)-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | tert-Butyl (5-chloro-4-fluoro-2-nitrophenyl)carbamate | HCID 46738284 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (4-Fluoro-2-nitro-5-pyrrolidin-1-yl-phenyl)-carbamic acid tert.-butyl ester | HCID 69688094 | — |
Reaction Steps
The title compound was prepared from (5-chloro-4-fluoro-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example B6) (5.81 g, 20 mmol) and pyrrolidine (8.27 mL, 100 mmol) in DMSO (40 mL) at 23° C. according to the general procedure C. Obtained as a yellow solid (6.42 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544985B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-3b5868bec1d44ddfb134f839f8bd28ac |
| Source note | uspto-grants-2003_04 |