HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → [5-(Cyclopropylmethyl-methyl-amino)-2-nitro-4-trifluoromethyl-phenyl]-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (Cyclopropylmethyl)(methyl)amine hydrochloride | HCID 12919210 | — |
| Reactant | (5-Chloro-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester | HCID 69489376 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | [5-(Cyclopropylmethyl-methyl-amino)-2-nitro-4-trifluoromethyl-phenyl]-carbamic acid tert.-butyl ester | HCID 69687558 | — |
Reaction Steps
The title compound was prepared from (5-chloro-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert.-butyl ester (Example B5) (5.11 g 15 mmol), cyclopropylmethyl-methyl-amine hydrochloride (5.47 g, 45 mmol) and Et3N (10.5 mL, 75 mmol) in DMSO (50 mL) at 23° C. according to the general procedure C. Obtained as a yellow solid (5.73 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544985B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-1176667bdb5743b78949cae6cd2b94aa |
| Source note | uspto-grants-2003_04 |