N-Methylpropylamine → HCID 69688073, compound

HRID 1265522Notes

Reaction equation

HRID 1265522 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12](Cl)[C:11]([CH3:15])=[CH:10][C:9]=1[N+:16]([O-:18])=[O:17])([CH3:4])([CH3:3])[CH3:2].[CH3:20][NH:21][CH2:22][CH2:23][CH3:24]>CS(C)=O>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([N:21]([CH3:20])[CH2:22][CH2:23][CH3:24])[C:11]([CH3:15])=[CH:10][C:9]=1[N+:16]([O-:18])=[O:17])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 12315N-MethylpropylamineHCID 69486680Carbamic acid, (5-chloro-4-methyl-2-nitrophenyl)-, 1,1-dimethylethyl ester

Product 1

HCID 69688073HCID 69688073, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The title compound was prepared from (5-chloro-4-methyl-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example B8) (3.5 g, 12.2 mmol) and N-methylpropylamine (6.5 ml, 61.0 mmol) in DMSO (35 mL) at 55° C. according to the general procedure C. Obtained as a yellow oil (3.89 g, 98%).

Sources & evidence

ORD record
ord-f549884305864dbeb17d25be26888e08
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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