HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylpropylamine → [4-Cyano-5-(methyl-propyl-amino)-2-nitro-phenyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylpropylamine | HCID 12315 | — |
| Reactant | 4-(Boc-amino)-2-fluoro-5-nitrobenzonitrile | HCID 69687274 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | [4-Cyano-5-(methyl-propyl-amino)-2-nitro-phenyl]-carbamic acid tert-butyl ester | HCID 69687961 | — |
Reaction Steps
The title compound was prepared from (4-cyano-5-fluoro-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example B9) (1.95 g, 6.93 mmol) and N-methyl-propylamine (3.72 ml, 34.7 mmol) in DMSO (20 mL) at RT according to the general procedure C. Obtained as a yellow solid (1.75 g, 75%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544985B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-e63693aa091d4117b57a34ec042d964b |
| Source note | uspto-grants-2003_04 |