HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → (4-Cyano-2-nitro-5-piperidin-1-yl-phenyl)-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-(Boc-amino)-2-fluoro-5-nitrobenzonitrile | HCID 69687274 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (4-Cyano-2-nitro-5-piperidin-1-yl-phenyl)-carbamic acid tert-butyl ester | HCID 69689072 | — |
Reaction Steps
The title compound was prepared from (4-cyano-5-fluoro-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example B9) (2.0 g, 7.11 mmol) and piperidine (3.51 ml, 35.6 mmol) in DMSO (20 mL) at RT according to the general procedure C. Obtained as a yellow solid (1.94 g, 79%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544985B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-49823c1d4186404b85439bfcddc4f665 |
| Source note | uspto-grants-2003_04 |