N-Methylisobutylamine → HCID 69687267, compound

HRID 1265536Notes

Reaction equation

HRID 1265536 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12](Cl)[C:11]([CH3:15])=[CH:10][C:9]=1[N+:16]([O-:18])=[O:17])([CH3:4])([CH3:3])[CH3:2].[CH2:20]([NH:24][CH3:25])[CH:21]([CH3:23])[CH3:22]>CS(C)=O>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([N:24]([CH2:20][CH:21]([CH3:23])[CH3:22])[CH3:25])[C:11]([CH3:15])=[CH:10][C:9]=1[N+:16]([O-:18])=[O:17])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 12249N-MethylisobutylamineHCID 69486680Carbamic acid, (5-chloro-4-methyl-2-nitrophenyl)-, 1,1-dimethylethyl ester

Product 1

HCID 69687267HCID 69687267, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The title compound was prepared from (5-chloro-4-methyl-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example B8) (3.01 g, 10.5 mmol) and N-isobutyl-methylamine (4.56 g, 52.3 mmol) in DMSO (30 mL) at 55° C. according to the general procedure C. Obtained as a yellow oil (1.84 g, 52%).

Sources & evidence

ORD record
ord-0752b8dbd34d471b929a9596c2db1818
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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