Isopropylamine → (4-Chloro-5-isopropylamino-2-nitro-phenyl)-carbamic acid tert-butyl ester

HRID 1265538Notes

Reaction equation

HRID 1265538 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12](Cl)[C:11]([Cl:15])=[CH:10][C:9]=1[N+:16]([O-:18])=[O:17])([CH3:4])([CH3:3])[CH3:2].[CH:20]([NH2:23])([CH3:22])[CH3:21]>CS(C)=O>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([NH:23][CH:20]([CH3:22])[CH3:21])[C:11]([Cl:15])=[CH:10][C:9]=1[N+:16]([O-:18])=[O:17])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 69489445HCID 69489445, compound

Product 1

HCID 69688645(4-Chloro-5-isopropylamino-2-nitro-phenyl)-carbamic acid tert-butyl ester

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The title compound was prepared from (4,5-dichloro-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example B2) (5.0 g, 16.3 mmol) and isopropylamine (7.0 ml, 81.4 mmol) in DMSO (35 mL) at 55° C. according to the general procedure C. Obtained as a brown solid (3.95 g, 73%).

Sources & evidence

ORD record
ord-81009f611b8d4d24a9b6a7f9546a8301
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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