(2,3-Difluorophenyl)boronic acid → (2-Dimethylamino-2',3'-difluoro-5-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

HRID 1265540Notes

Reaction equation

HRID 1265540 reaction equation
[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11](I)=[CH:10][C:9]=1[N+:18]([O-:20])=[O:19])([CH3:4])([CH3:3])[CH3:2].[F:22][C:23]1[C:28]([F:29])=[CH:27][CH:26]=[CH:25][C:24]=1B(O)O>>[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[C:9]([N+:18]([O-:20])=[O:19])=[CH:10][C:11]([C:27]2[CH:26]=[CH:25][CH:24]=[C:23]([F:22])[C:28]=2[F:29])=[C:12]([N:14]([CH3:16])[CH3:15])[CH:13]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 2734333(2,3-Difluorophenyl)boronic acidHCID 69688196HCID 69688196, compound

Product 1

HCID 69688091(2-Dimethylamino-2',3'-difluoro-5-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

Procedure

The title compound was prepared from (5-dimethylamino-4-iodo-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example C2) and 2,3-difluorophenylboronic acid according to the general procedure D. Obtained as a yellow solid (3.096 g).

Sources & evidence

ORD record
ord-6750199ccbe149c8aa879f7a016c9b5a
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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