2-Fluorophenylboronic acid → HCID 69486785, compound

HRID 1265542Notes

Reaction equation

HRID 1265542 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([Cl:14])[C:11](I)=[CH:10][C:9]=1[N+:16]([O-:18])=[O:17])([CH3:4])([CH3:3])[CH3:2].[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1B(O)O>>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[C:9]([N+:16]([O-:18])=[O:17])=[CH:10][C:11]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[F:20])=[C:12]([Cl:14])[CH:13]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27343542-Fluorophenylboronic acidHCID 21349844HCID 21349844, compound

Product 1

HCID 69486785HCID 69486785, compound

Procedure

The title compound was prepared from (5-chloro-4-iodo-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example 1) (30 g, 75.3 mmol) and 2-fluorophenylboronic acid (13.82 g, 98.8 mmol) according to the general procedure D. Obtained as a yellow gum (1.39 g).

Sources & evidence

ORD record
ord-701340b1bf2745ec8aefb19ba455b319
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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