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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1265546Generated: November 3, 2026

Stannous chloride dihydrate → Carbamic acid,[2-amino-4-chloro-5-[(2-methoxyethyl)methylamino]phenyl]-,1,1-dimethylethyl ester

https://huagongshe.com/reaction/1265546

Reaction equation

Participants

RoleNameHCIDCharge
ReactantStannous chloride dihydrateHCID 61436—
Reactant{4-Chloro-5-[(2-methoxy-ethyl)-methyl-amino]-2-nitro-phenyl}-carbamic acid tert.-butyl esterHCID 69688832—
ProductCarbamic acid,[2-amino-4-chloro-5-[(2-methoxyethyl)methylamino]phenyl]-,1,1-dimethylethyl esterHCID 69687800—

Reaction Steps

The title compound was prepared from {4-chloro-5-[(2-methoxy-ethyl)-methyl-amino]-2-nitro-phenyl}-carbamic acid tert.-butyl ester (Example C3) (3.46 g, 9.62 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as a yellow solid (2.25 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06544985B2
Source datasetuspto-grants-2003_04
ORD IDord-b4e00787e8324f459902f897359abede
Source noteuspto-grants-2003_04