HCID 69688386, compound → HCID 69688642, compound

HRID 1265547Notes

Reaction equation

HRID 1265547 reaction equation
[C:1]([O:5][C:6](=[O:30])[NH:7][C:8]1[C:13]([N+:14]([O-])=O)=[CH:12][C:11]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[F:23])=[C:10]([O:24][CH2:25][C:26]([F:29])([F:28])[F:27])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:30])[NH:7][C:8]1[C:13]([NH2:14])=[CH:12][C:11]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[F:23])=[C:10]([O:24][CH2:25][C:26]([F:27])([F:28])[F:29])[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 69688386HCID 69688386, compound

Product 1

HCID 69688642HCID 69688642, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The title compound was prepared from [2′-fluoro-5-nitro-2-(2,2,2-trifluoro-ethoxy)-biphenyl-4-yl]-carbamic acid tert.-butyl ester (Example D2) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as a grey solid (1.17 g).

Sources & evidence

ORD record
ord-f3f90e85cc904a698121178f535227d2
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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