(4-Fluoro-2-nitro-5-pyrrolidin-1-yl-phenyl)-carbamic acid tert.-butyl ester → HCID 69688999, compound

HRID 1265557Notes

Reaction equation

HRID 1265557 reaction equation
[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[C:11]([F:19])=[CH:10][C:9]=1[N+:20]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[C:11]([F:19])=[CH:10][C:9]=1[NH2:20])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 69688094(4-Fluoro-2-nitro-5-pyrrolidin-1-yl-phenyl)-carbamic acid tert.-butyl ester

Product 1

HCID 69688999HCID 69688999, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The title compound was prepared from (4-fluoro-2-nitro-5-pyrrolidin-1-yl-phenyl)-carbamic acid tert.-butyl ester (Example C13) (6.37 g, 20 mmol) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as a grey solid (5.92 g).

Sources & evidence

ORD record
ord-b31bdc7e86874499a62cdb5350f51949
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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