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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1265577Generated: October 25, 2026

[5-(Methyl-propyl-amino)-2-nitro-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester → Carbamic acid,[2-amino-5-(methylpropylamino)-4-(trifluoromethyl)phenyl]-,1,1-dimethylethyl ester

https://huagongshe.com/reaction/1265577

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[5-(Methyl-propyl-amino)-2-nitro-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl esterHCID 69487144—
CatalystPalladiumHCID 23938—
ProductCarbamic acid,[2-amino-5-(methylpropylamino)-4-(trifluoromethyl)phenyl]-,1,1-dimethylethyl esterHCID 69486655—

Reaction Steps

The title compound was prepared from [5-(methyl-propyl-amino)-2-nitro-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example C32) (3.78 g, 10.0 mmol) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as a red oil (3.40 g, 98%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06544985B2
Source datasetuspto-grants-2003_04
ORD IDord-bb87b000eeff45c0ad61c949011ef32f
Source noteuspto-grants-2003_04