Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1265578Generated: November 3, 2026

[5-(Isobutyl-methyl-amino)-2-nitro-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester → Carbamic acid,n-[2-amino-5-[methyl(2-methylpropyl)amino]-4-(trifluoromethyl)phenyl]-,1,1-dimethylethyl ester

https://huagongshe.com/reaction/1265578

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[5-(Isobutyl-methyl-amino)-2-nitro-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl esterHCID 69489328—
CatalystPalladiumHCID 23938—
ProductCarbamic acid,n-[2-amino-5-[methyl(2-methylpropyl)amino]-4-(trifluoromethyl)phenyl]-,1,1-dimethylethyl esterHCID 67361123—

Reaction Steps

The title compound was prepared from [5-(isobutyl-methyl-amino)-2-nitro-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example C33) (3.88 g, 9.91 mmol) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as a orange oil (2.70 g, 75%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06544985B2
Source datasetuspto-grants-2003_04
ORD IDord-6e5a812984d44bf7900d7ecf21ea7d24
Source noteuspto-grants-2003_04