HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → HCID 69687567, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | Ethyl 3-ethynylbenzoate | HCID 15540684 | — |
| Reactant | Methyl 3-(3-methoxymethyl-isoxazol-5-yl)-benzoate | HCID 18548718 | — |
| Reactant | HCID 73450284 | HCID 73450284 | — |
| Reactant | Lithium Tert-butyl Acetate | HCID 86586795 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 69687567 | HCID 69687567 | — |
Reaction Steps
The title compound was prepared from methyl 3-(3-methoxymethyl-isoxazol-5-yl)-benzoate [prepared by reaction of ethyl 3-ethynylbenzoate [CAS-No. 178742-95-5] with a mixture of NCS, 2-methoxyacetaldoxime [CAS-No. 71494-93-4], Et3N and cat. amount of pyridine in CHCl3 at 50° C. according to Tetrahedron 1984, 40, 2985-2988] by treatment with lithium tert.-butyl acetate according to general procedure K (method b). Obtained as a light yellow liquid (1.548 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544985B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-369ae7ed22f04edd8f0f1357deacb4c2 |
| Source note | uspto-grants-2003_04 |