HuagongsheHuagongshe Chemistry Print Report · For research reference only
Magnesium Chloride → 3-Oxo-3-(3-[1,2,3]triazol-1-yl-phenyl)-propionic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Magnesium Chloride | HCID 5360315 | — |
| Reactant | ethyl chloroformate Et3N | HCID 19692316 | — |
| Reactant | 3-(1H-1,2,3-triazol-1-yl)benzoic acid | HCID 22224853 | — |
| Reactant | HCID 23662309 | HCID 23662309 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 3-Oxo-3-(3-[1,2,3]triazol-1-yl-phenyl)-propionic acid tert-butyl ester | HCID 69687599 | — |
Reaction Steps
The title compound was prepared from 3-[1,2,3]triazol-1-yl-benzoic acid [prepared by refluxing of methyl 3-azidobenzoate [CAS-No. 93066-93-4] in trimethylsilyl-acetylene, followed by saponification with aqueous NaOH in refluxing EtOH] (10.0 g, 52.86 mmol) by activation with ethyl chloroformate/Et3N and reaction with mono tert.-butyl malonate potassium salt with Et3N and MgCl2 in CH3CN according to general procedure K (method a). Obtained as an orange oil (11.55 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544985B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-08b3207d42334432ad99d1837318d639 |
| Source note | uspto-grants-2003_04 |