HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1265600Generated: October 30, 2026
Acetamide → 3-(2-Methyl-oxazol-4-yl)-benzoic acid
https://huagongshe.com/reaction/1265600
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetamide | HCID 178 | — |
| Reactant | 3-(2-bromoacetyl)benzoic Acid | HCID 2756835 | — |
| Product | 3-(2-Methyl-oxazol-4-yl)-benzoic acid | HCID 18613159 | 74.3% |
Reaction Steps
A mixture of 3-(2-bromo-acetyl)-benzoic acid (2.43 g) and acetamide (1.77 g) was heated with stirring to 130° C. for 40 min. The mixture was cooled and diluted with H2(30 mL) and the precipitate formed was collected by filtration to give 3-(2-methyl-oxazol-4-yl)-benzoic acid (1.51 g) as brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06544985B2 |
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| Source dataset | uspto-grants-2003_04 |
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| ORD ID | ord-1fbba387afe0432ea075cd882750885f |
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| Source note | uspto-grants-2003_04 |
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