3-Thiazol-4-yl-benzoic acid methyl ester → 3-Oxo-3-(3-thiazol-4-yl-phenyl)-propionic acid tert-butyl ester

HRID 1265612Notes

Reaction equation

HRID 1265612 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[CH:12][S:13][CH:14]=2)[CH:5]=1.[C:16]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])(=[O:18])[CH3:17].[Li]>>[C:20]([O:19][C:16](=[O:18])[CH2:17][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[CH:12][S:13][CH:14]=2)[CH:5]=1)([CH3:23])([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 696880593-Thiazol-4-yl-benzoic acid methyl esterHCID 86586795Lithium Tert-butyl Acetate

Product 1

HCID 696875143-Oxo-3-(3-thiazol-4-yl-phenyl)-propionic acid tert-butyl ester

Procedure

3-Thiazol-4-yl-benzoic acid methyl ester (0.91 g) was treated with lithium tert.-butyl acetate according to the general procedure K (method b) to give crude 3-oxo-3-(3-thiazol-4-yl-phenyl)-propionic acid tert-butyl ester (1.54 g) as a pale-yellow oil.

Sources & evidence

ORD record
ord-530f696ae28b487cac47d42211c1453e
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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