3-(2-Methyl-5-propyl-oxazol-4-yl)-benzoic acid methyl ester → 3-[3-(2-Methyl-5-propyl-oxazol-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester

HRID 1265619Notes

Reaction equation

HRID 1265619 reaction equation
CO[C:3](=[O:19])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[C:12]([CH3:18])[O:13][C:14]=2[CH2:15][CH2:16][CH3:17])[CH:5]=1.[C:20]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])(=[O:22])[CH3:21].[Li]>>[C:24]([O:23][C:20](=[O:22])[CH2:21][C:3]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[C:12]([CH3:18])[O:13][C:14]=2[CH2:15][CH2:16][CH3:17])[CH:5]=1)=[O:19])([CH3:27])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 696875703-(2-Methyl-5-propyl-oxazol-4-yl)-benzoic acid methyl esterHCID 86586795Lithium Tert-butyl Acetate

Product 1

HCID 696882243-[3-(2-Methyl-5-propyl-oxazol-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester

Procedure

3-(2-Methyl-5-propyl-oxazol-4-yl)-benzoic acid methyl ester (0.47 g) was treated with lithium tert.-butyl acetate according to the general procedure K (method b) to give crude 3-[3-(2-methyl-5-propyl-oxazol-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (0.58 g) as a light-brown oil.

Sources & evidence

ORD record
ord-6165d51b602644d08d6833f519614faf
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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