3-(5-Methyl-thiazol-4-yl)-benzoic acid methyl ester → 3-[3-(5-Methyl-thiazol-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester

HRID 1265621Notes

Reaction equation

HRID 1265621 reaction equation
CO[C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[CH:12][S:13][C:14]=2[CH3:15])[CH:5]=1.[C:17]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])(=[O:19])[CH3:18].[Li]>>[C:21]([O:20][C:17](=[O:19])[CH2:18][C:3]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[CH:12][S:13][C:14]=2[CH3:15])[CH:5]=1)=[O:16])([CH3:24])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 696892723-(5-Methyl-thiazol-4-yl)-benzoic acid methyl esterHCID 86586795Lithium Tert-butyl Acetate

Product 1

HCID 696886003-[3-(5-Methyl-thiazol-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester

Procedure

A sample of 3-(5-methyl-thiazol-4-yl)-benzoic acid methyl ester (1.05 g) was treated with lithium tert.-butyl acetate according to the general procedure K (method b) to give crude 3-[3-(5-methyl-thiazol-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (1.9 g) as a pale-yellow oil.

Sources & evidence

ORD record
ord-94d21c8108914374bab9c0bc8544f45d
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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