反应详情

温度

60 °C

A sample of rac-3-(2-bromo-pentanoyl)-benzoic acid methyl ester (0.60 g) and and 2-(tert.-butylcarbonyloxy)thioacetamide (0.36 g) in EtOH (4 mL) was heated at reflux for 5 h. The mixture was partitioned between AcOEt and 5% NaHCO3 solution, the organic layer was washed with brine, dried and evaporated. A solution of the residual oil and of NaOMe (0.13 g) in MeOH (10 mL) was stirred at 60° C. for 30 min. The solution was diluted with AcOEt, washed with 1N HCl and brine, dried and evaporated to give 3-(2-hydroxymethyl-5-methyl-thiazol-4-yl)-benzoic acid methyl ester (0.44 g) as an oil.

1. temperatureat reflux for 5 h
2. customThe mixture was partitioned between AcOEt and 5% NaHCO3 solution
3. washthe organic layer was washed with brine
4. customdried
5. customevaporated
6. additionThe solution was diluted with AcOEt
7. washwashed with 1N HCl and brine
8. customdried
9. customevaporated