3-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile → HCID 86586802, compound

HRID 1265645Notes

Reaction equation

HRID 1265645 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11](Cl)=[CH:10][C:9]=1[NH2:18])([CH3:4])([CH3:3])[CH3:2].CC1(C)[O:26][C:25]([C:27]2[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=2)[C:30]#[N:31])=[CH:24][C:23](=[O:35])O1>>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([C:24]#[C:25][C:27]2[CH:28]=[CH:29][CH:32]=[CH:33][CH:34]=2)=[CH:10][C:9]=1[NH:18][C:23](=[O:35])[CH2:24][C:25]([C:27]1[CH:34]=[CH:33][CH:32]=[C:29]([C:30]#[N:31])[CH:28]=1)=[O:26])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 117363373-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrileHCID 69688689(2-Amino-4-chloro-5-dimethylamino-phenyl)-carbamic acid tert.-butyl ester

Product 1

HCID 86586802HCID 86586802, compound

Procedure

The title compound was prepared from (2-amino-4-chloro-5-dimethylamino-phenyl)-carbamic acid tert.-butyl ester (Example J2) and 3-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile (Example L1) according to the general procedure M. Obtained as an orange solid (108 mg).

Sources & evidence

ORD record
ord-09f160d58c534f57849f592c27c9766a
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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