3-Oxo-3-(3-[1,2,3)triazol-1-yl-phenyl)-propionic acid ethyl ester → HCID 86586803, compound

HRID 1265646Notes

Reaction equation

HRID 1265646 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11](Cl)=[CH:10][C:9]=1[NH2:18])([CH3:4])([CH3:3])[CH3:2].C(O[C:23](=[O:38])[CH2:24][C:25](=[O:37])[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([N:32]2[CH:36]=[CH:35][N:34]=[N:33]2)[CH:27]=1)C>>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([C:24]#[C:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[CH:10][C:9]=1[NH:18][C:23](=[O:38])[CH2:24][C:25](=[O:37])[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([N:32]2[CH:36]=[CH:35][N:34]=[N:33]2)[CH:27]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 695928683-Oxo-3-(3-[1,2,3)triazol-1-yl-phenyl)-propionic acid ethyl esterHCID 69688689(2-Amino-4-chloro-5-dimethylamino-phenyl)-carbamic acid tert.-butyl ester

Product 1

HCID 86586803HCID 86586803, compound

Procedure

The title compound was prepared from (2-amino-4-chloro-5-dimethylamino-phenyl)-carbamic acid tert.-butyl ester (Example J2) and 3-oxo-3-(3-[1,2,3]triazol-1-yl-phenyl)-propionic acid ethyl ester (Example K1) according to the general procedure M. Obtained as an orange solid (148 mg).

Sources & evidence

ORD record
ord-267d8c7b95b84ccba2d01441e862b845
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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