HRID1265663

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)OC(=O)C=C(c2cccc(-n3ccnc3)c2)O1

HCID22224895

未命名化合物

结构：CC(C)(C)OC(=O)Nc1cc(OCC(F)(F)F)c(-c2ccccc2F)cc1N

HCID69688642

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)Nc1cc(OCC(F)(F)F)c(-c2ccccc2F)cc1NC(=O)CC(=O)c1cccc(-n2ccnc2)c1

HCID86586909

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from [5-amino-2′-fluoro-2-(2,2,2-trifluoro-ethoxy)-biphenyl-4-yl]-carbamic acid tert.-butyl ester (Example J5) (200 mg, 0.5 mmol) and 6-(3-imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one (Example L3) (160 mg, 0.5 mmol) according to the general procedure M. Obtained as an amorphous brown substance (167 mg).

WORKUP

后处理

customObtained as an amorphous brown substance (167 mg)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-374d266206c64df99af7a5909845f48c
来源数据集: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06544985B2
来源说明: uspto-grants-2003_04

反应 SMILES

[C:1]([O:5][C:6](=[O:28])[NH:7][C:8]1[C:13]([NH2:14])=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[N:29]1([C:34]2[CH:35]=[C:36]([C:40]3[O:45]C(C)(C)[O:43][C:42](=O)[CH:41]=3)[CH:37]=[CH:38][CH:39]=2)[CH:33]=[CH:32][N:31]=[CH:30]1>>[C:1]([O:5][C:6](=[O:28])[NH:7][C:8]1[C:13]([NH:14][C:42](=[O:43])[CH2:41][C:40]([C:36]2[CH:37]=[CH:38][CH:39]=[C:34]([N:29]3[CH:33]=[CH:32][N:31]=[CH:30]3)[CH:35]=2)=[O:45])=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([O:22][CH2:23][C:24]([F:25])([F:26])[F:27])[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]