6-(3-Imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one → HCID 86586909, compound

HRID 1265663Notes

Reaction equation

HRID 1265663 reaction equation
[C:1]([O:5][C:6](=[O:28])[NH:7][C:8]1[C:13]([NH2:14])=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[N:29]1([C:34]2[CH:35]=[C:36]([C:40]3[O:45]C(C)(C)[O:43][C:42](=O)[CH:41]=3)[CH:37]=[CH:38][CH:39]=2)[CH:33]=[CH:32][N:31]=[CH:30]1>>[C:1]([O:5][C:6](=[O:28])[NH:7][C:8]1[C:13]([NH:14][C:42](=[O:43])[CH2:41][C:40]([C:36]2[CH:37]=[CH:38][CH:39]=[C:34]([N:29]3[CH:33]=[CH:32][N:31]=[CH:30]3)[CH:35]=2)=[O:45])=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([O:22][CH2:23][C:24]([F:25])([F:26])[F:27])[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 222248956-(3-Imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-oneHCID 69688642HCID 69688642, compound

Product 1

HCID 86586909HCID 86586909, compound

Procedure

The title compound was prepared from [5-amino-2′-fluoro-2-(2,2,2-trifluoro-ethoxy)-biphenyl-4-yl]-carbamic acid tert.-butyl ester (Example J5) (200 mg, 0.5 mmol) and 6-(3-imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one (Example L3) (160 mg, 0.5 mmol) according to the general procedure M. Obtained as an amorphous brown substance (167 mg).

Workup

  1. customObtained as an amorphous brown substance (167 mg)

Sources & evidence

ORD record
ord-374d266206c64df99af7a5909845f48c
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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