3-Oxo-3-(3-[1,2,3)triazol-1-yl-phenyl)-propionic acid ethyl ester → HCID 86586820, compound

HRID 1265665Notes

Reaction equation

HRID 1265665 reaction equation
[C:1]([O:5][C:6](=[O:28])[NH:7][C:8]1[C:13]([NH2:14])=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].C([O:31][C:32](=O)[CH2:33][C:34](=[O:46])[C:35]1[CH:40]=[CH:39][CH:38]=[C:37]([N:41]2[CH:45]=[CH:44][N:43]=[N:42]2)[CH:36]=1)C>>[C:1]([O:5][C:6](=[O:28])[NH:7][C:8]1[C:13]([NH:14][C:32](=[O:31])[CH2:33][C:34](=[O:46])[C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([N:41]3[CH:45]=[CH:44][N:43]=[N:42]3)[CH:36]=2)=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([O:22][CH2:23][C:24]([F:25])([F:26])[F:27])[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 695928683-Oxo-3-(3-[1,2,3)triazol-1-yl-phenyl)-propionic acid ethyl esterHCID 69688642HCID 69688642, compound

Product 1

HCID 86586820HCID 86586820, compound

Procedure

The title compound was prepared from [5-amino-2′-fluoro-2-(2,2,2-trifluoro-ethoxy)-biphenyl-4-yl]-carbamic acid tert.-butyl ester (Example J5) (200 mg, 0.5 mmol) and 3-oxo-3-(3-[1,2,3]triazol-1-yl-phenyl)-propionic acid ethyl ester (Example K1) (150 mg, 0.57 mmol) according to the general procedure M. Obtained as a light yellow solid (110 mg).

Sources & evidence

ORD record
ord-27e4d55522794802b73903edb684d054
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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