HRID1265666

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)CC(=O)c1cccc(-n2nncc2COC2CCCCO2)c1

HCID12048028

未命名化合物

结构：CC(C)(C)OC(=O)Nc1cc(OCC(F)(F)F)c(-c2ccccc2F)cc1N

HCID69688642

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)Nc1cc(OCC(F)(F)F)c(-c2ccccc2F)cc1NC(=O)CC(=O)c1cccc(-n2nncc2COC2CCCCO2)c1

HCID86586821

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from [5-amino-2′-fluoro-2-(2,2,2-trifluoro-ethoxy)-biphenyl-4-yl]-carbamic acid tert.-butyl ester (Example J5) (200 mg, 0.5 mmol) and (RS)-3-oxo-3-{3-[5-(tetrahydro-pyran-2-yloxymethyl)-[1,2,3]triazol-1-yl]-phenyl}-propionic acid tert-butyl ester (Example K5) (220 mg, 0.55 mmol) according to the general procedure M. Obtained as a yellow oil(100 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-25ddd3d2b1f54812a5d3c4979123e3ae
来源数据集: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06544985B2
来源说明: uspto-grants-2003_04

反应 SMILES

[C:1]([O:5][C:6](=[O:28])[NH:7][C:8]1[C:13]([NH2:14])=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].C([O:33][C:34](=O)[CH2:35][C:36](=[O:56])[C:37]1[CH:42]=[CH:41][CH:40]=[C:39]([N:43]2[C:47]([CH2:48][O:49][CH:50]3[CH2:55][CH2:54][CH2:53][CH2:52][O:51]3)=[CH:46][N:45]=[N:44]2)[CH:38]=1)(C)(C)C>>[C:1]([O:5][C:6](=[O:28])[NH:7][C:8]1[C:13]([NH:14][C:34](=[O:33])[CH2:35][C:36](=[O:56])[C:37]2[CH:42]=[CH:41][CH:40]=[C:39]([N:43]3[C:47]([CH2:48][O:49][CH:50]4[CH2:55][CH2:54][CH2:53][CH2:52][O:51]4)=[CH:46][N:45]=[N:44]3)[CH:38]=2)=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([O:22][CH2:23][C:24]([F:25])([F:26])[F:27])[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]