HRID1265670

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F

HCID67362752

未命名化合物

反应SMILES：Cn1nccc1-c1cccc(C(=O)CC(=O)OC(C)(C)C)c1

HCID69688564

未命名化合物

PRODUCTS

产物

反应SMILES：CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-c3ccnn3C)c2)cc1C(F)(F)F

HCID86586826

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from (2-amino-5-dimethylamino-4-trifluoromethyl-phenyl)-carbamic acid tert.-butyl ester (Example J6) (160 mg, 0.5 mmol) and 3-[3-(2-methyl-2H-pyrazol-3-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester (Example K7) (150 mg, 0.5 mmol) according to the general procedure M. Obtained as a yellow foam (90 mg).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-b57835f9e23a48758639bb66f7b5af9d
来源数据集: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06544985B2
来源说明: uspto-grants-2003_04

反应SMILES

[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH2:21])([CH3:4])([CH3:3])[CH3:2].C([O:27][C:28](=O)[CH2:29][C:30]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([C:38]2[N:39]([CH3:43])[N:40]=[CH:41][CH:42]=2)[CH:33]=1)=[O:31])(C)(C)C>>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH:21][C:28](=[O:27])[CH2:29][C:30]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([C:38]2[N:39]([CH3:43])[N:40]=[CH:41][CH:42]=2)[CH:33]=1)=[O:31])([CH3:4])([CH3:2])[CH3:3]