3-(2-Cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl ester → HCID 86586842, compound

HRID 1265684Notes

Reaction equation

HRID 1265684 reaction equation
[C:1]([O:5][C:6](=[O:20])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:17][CH2:16][CH2:15]2)[C:11]([Cl:18])=[CH:10][C:9]=1[NH2:19])([CH3:4])([CH3:3])[CH3:2].C([O:25][C:26](=O)[CH2:27][C:28]([C:30]1[CH:35]=[CH:34][N:33]=[C:32]([C:36]#[N:37])[CH:31]=1)=[O:29])(C)(C)C>>[C:1]([O:5][C:6](=[O:20])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:17][CH2:16][CH2:15]2)[C:11]([Cl:18])=[CH:10][C:9]=1[NH:19][C:26](=[O:25])[CH2:27][C:28]([C:30]1[CH:35]=[CH:34][N:33]=[C:32]([C:36]#[N:37])[CH:31]=1)=[O:29])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 695928163-(2-Cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl esterHCID 69688803HCID 69688803, compound

Product 1

HCID 86586842HCID 86586842, compound

Procedure

The title compound was prepared from (2-amino-5-azetidin-1-yl-4-chloro-phenyl)-carbamic acid tert.-butyl ester (Example J16) and 3-(2-cyano-pyridin-4-yl)-3-oxo-propionic acid tert.-butyl ester (Example K3) according to the general procedure M. Obtained as a yellow solid (142 mg).

Sources & evidence

ORD record
ord-220c68bc2b604c259ea929ae4b75c351
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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