HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl ester → {5-Azetidin-1-yl-2-[3-(2-cyano-pyridin-4-yl)-3-oxo-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl ester | HCID 69592816 | — |
| Reactant | (2-Amino-5-azetidin-1-yl-4-trifluoromethyl-phenyl)-carbamic acid tert.-butyl ester | HCID 69687698 | — |
| Product | {5-Azetidin-1-yl-2-[3-(2-cyano-pyridin-4-yl)-3-oxo-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert.-butyl ester | HCID 86586844 | — |
Reaction Steps
The title compound was prepared from (2-amino-5-azetidin-1-yl-4-trifluoromethyl-phenyl)-carbamic acid tert.-butyl ester (Example J17) and 3-(2-cyano-pyridin-4-yl)-3-oxo-propionic acid tert.-butyl ester (Example K3) according to the general procedure M. Obtained as a light yellow solid (131 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544985B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-204754c5cd7e4ecc967edb4de1dc1319 |
| Source note | uspto-grants-2003_04 |