HRID1265701

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)OC(=O)C=C(c2cccc(-n3ccnn3)c2)O1

HCID18548744

未命名化合物

结构：CN(C)c1cc(NC(=O)OC(C)(C)C)c(N)cc1-c1ccccc1F

HCID69489440

未命名化合物

PRODUCTS

生成物

结构：CN(C)c1cc(NC(=O)OC(C)(C)C)c(NC(=O)CC(=O)c2cccc(-n3ccnn3)c2)cc1-c1ccccc1F

HCID86586862

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from (5-amino-2-dimethylamino-2′-fluoro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example J20) (691 mg, 2.0 mmol) and 2,2-dimethyl-6-(3-[1,2,3]triazol-1-yl-phenyl)-[1,3]dioxin-4-one (Example L4) (543 mg, 2.0 mmol) according to the general procedure M. Obtained as a yellow solid (820 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-42a34710040a41f7ab59ab3fb29c7a86
来源数据集: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06544985B2
来源说明: uspto-grants-2003_04

反应 SMILES

[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[C:13]([NH2:14])=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([N:22]([CH3:24])[CH3:23])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].CC1(C)[O:32][C:31](=O)[CH:30]=[C:29]([C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([N:40]3[CH:44]=[CH:43][N:42]=[N:41]3)[CH:35]=2)[O:28]1>>[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[C:13]([NH:14][C:31](=[O:32])[CH2:30][C:29](=[O:28])[C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([N:40]3[CH:44]=[CH:43][N:42]=[N:41]3)[CH:35]=2)=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([N:22]([CH3:23])[CH3:24])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]