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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1265739Generated: October 29, 2026

HCID 69486615, compound → [2-[3-(2-Cyano-pyridin-4-yl)-3-oxo-propionylamino]-5-(isopropyl-methyl-amino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/1265739

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 69486615HCID 69486615—
Reactant3-(2-Cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl esterHCID 69592816—
Product[2-[3-(2-Cyano-pyridin-4-yl)-3-oxo-propionylamino]-5-(isopropyl-methyl-amino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl esterHCID 86586925—

Reaction Steps

The title compound was prepared from [2-amino-5-(isoproyl-methyl-amino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example J37) (500 mg, 1.44 mmol) and 3-(2-cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl ester (Example K3) (355 mg, 1.44 mmol) according to the general procedure M. Obtained as a light orange oil (670 mg, 90%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06544985B2
Source datasetuspto-grants-2003_04
ORD IDord-b3b252a5410c4116a9cf336c997a5db3
Source noteuspto-grants-2003_04