HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 8-Chloro-7-dimethylamino-4-[3-(4-hydroxymethyl-pyrazol-1-yl)-phenyl]-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (RS)-[4-Chloro-5-dimethylamino-2-(3-oxo-3-{3-[4-(tetrahydro-pyran-2-yloxymethyl)-pyrazol-1-yl]-phenyl}-propionylamino)-phenyl]-carbamic acid tert.-butyl ester | HCID 86586850 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Chloro-7-dimethylamino-4-[3-(4-hydroxymethyl-pyrazol-1-yl)-phenyl]-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 18613328 | — |
Reaction Steps
The title compound was prepared from (RS)-[4-chloro-5-dimethylamino-2-(3-oxo-3-{3-[4-(tetrahydro-pyran-2-yloxymethyl)-pyrazol-1-yl]-phenyl}-propionylamino)-phenyl]-carbamic acid tert.-butyl ester (Example M58) (642 mg, 1.05 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (365 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544985B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-34870bb295774179a4b5e0f768f87968 |
| Source note | uspto-grants-2003_04 |