HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 8-Methyl-4-[3-(3-methyl-isoxazol-5-yl)-phenyl]-7-pyrrolidin-1-yl-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (4-Methyl-2-{3-[3-(3-methyl-isoxazol-5-yl)-phenyl]-3-oxo-propionylamino}-5-pyrrolidin-1-yl-phenyl)-carbamic acid tert-butyl ester | HCID 86586894 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Methyl-4-[3-(3-methyl-isoxazol-5-yl)-phenyl]-7-pyrrolidin-1-yl-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 18613251 | — |
Reaction Steps
The title compound was prepared from (4-methyl-2-{3-[3-(3-methyl-isoxazol-5-yl)-phenyl]-3-oxo-propionylamino}-5-pyrrolidin-1-yl-phenyl)-carbamic acid tert-butyl ester (Example M111) (0.33 g, 0.64 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (223 mg, 87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544985B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-2e870f25ee9046c98e4d16985cfab607 |
| Source note | uspto-grants-2003_04 |