HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloride → 8-Chloro-7-(isopropyl-methyl-amino)-4-(3-{5-[(isopropyl-methyl-amino)-methyl]-[1,2,3]triazol-1-yl}-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | N-Methylisopropylamine | HCID 78485 | — |
| Reactant | 8-Chloro-4-[3-(5-hydroxymethyl-[1,2,3]triazol-1-yl)-phenyl]-7-(isopropyl-methyl-amino)-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 18613108 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Chloro-7-(isopropyl-methyl-amino)-4-(3-{5-[(isopropyl-methyl-amino)-methyl]-[1,2,3]triazol-1-yl}-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 10300265 | — |
Reaction Steps
The title compound was prepared from 8-chloro-4-[3-(5-hydroxymethyl-[1,2,3]triazol-1-yl)-phenyl]-7-(isopropyl-methyl-amino)-1,3-dihydro-benzo[b][1,4]diazepin-2-one (Example 96) (220 mg, 0.50 mmol) by reaction with thionylchloride in dichloromethane and subsequent treatment of the corresponding chloride with N-isopropylmethylamine in DMF according to the method described in Example 45. Obtained as a light yellow solid (120 mg, 49%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544985B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-5219a5e859d440adbb3990ce25b39aa6 |
| Source note | uspto-grants-2003_04 |