HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1265919Generated: November 2, 2026
Thionyl Chloride → 8-Chloro-4-[3-(4-chloromethyl-thiazol-2-yl)-phenyl]-7-dimethylamino-1,3-dihydro-benzo[b][1,4]diazepin-2-one
https://huagongshe.com/reaction/1265919
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 8-Chloro-7-dimethylamino-4-[3-(4-hydroxymethyl-thiazol-2-yl)-phenyl]-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 18613361 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Chloro-4-[3-(4-chloromethyl-thiazol-2-yl)-phenyl]-7-dimethylamino-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 18613213 | — |
Reaction Steps
A mixture of 8-chloro-7-dimethylamino-4-[3-(4-hydroxymethyl-thiazol-2-yl)-phenyl]-1,3-dihydro-benzo[b][1,4]diazepin-2-one (0.38 g) (Example 19) and thionyl chloride (0.1 mL) in CH2Cl2 was heated to 40° C. for 2 h. The heterogeneous mixture was evaporated in vacuum and the residue was triturated with AcOEt to give the title compound (0.44 g) as a light-brown solid, MS (ISP) 445.1 [(M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06544985B2 |
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| Source dataset | uspto-grants-2003_04 |
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| ORD ID | ord-f61b9fcf60604afba56630d10a37a03e |
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| Source note | uspto-grants-2003_04 |
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