HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1265924Generated: November 3, 2026
Thiourea → 4-[3-(2-Amino-thiazol-4-yl)-phenyl]-8-chloro-7-dimethylamino-1,3-dihydro-benzo[b][1,4]diazepin-2-one
https://huagongshe.com/reaction/1265924
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 4-(3-Bromoacetyl-phenyl)-8-chloro-7-dimethylamino-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 18613234 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-[3-(2-Amino-thiazol-4-yl)-phenyl]-8-chloro-7-dimethylamino-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 18613499 | 20.2% |
Reaction Steps
A mixture of 4-(3-bromoacetyl-phenyl)-8-chloro-7-dimethylamino-1,3-dihydro-benzo[b][1,4]diazepin-2-one (0.73 g) (Example 193a) and thiourea (0.13 g) in THF (10 mL) was heated to 60° C. for 15 min. The mixture was diluted with AcOEt and washed with sat. NaHCO3 solution and with brine. The organic layer was dried and evaporated and the residue was stirred with CH2Cl2 to give the title compound (0.14 g) as yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06544985B2 |
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| Source dataset | uspto-grants-2003_04 |
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| ORD ID | ord-d36c659a66744f32910c26c62bb79f84 |
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| Source note | uspto-grants-2003_04 |
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