Sodium Chloride → Moxifloxacin

HRID 1265944Notes

Reaction equation

HRID 1265944 reaction equation
[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:17][C@@H:16]3[C@@H:11]([CH2:12][CH2:13][CH2:14][NH:15]3)[CH2:10]2)=[C:7]([F:18])[CH:6]=[C:5]2[C:19]([C:21]([C:27]([OH:29])=[O:28])=[CH:22][N:23]([CH:24]3[CH2:26][CH2:25]3)[C:4]=12)=[O:20].Cl.[Cl-].[Na+]>O>[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:17][C@@H:16]3[C@@H:11]([CH2:12][CH2:13][CH2:14][NH:15]3)[CH2:10]2)=[C:7]([F:18])[CH:6]=[C:5]2[C:19]([C:21]([C:27]([OH:29])=[O:28])=[CH:22][N:23]([CH:24]3[CH2:26][CH2:25]3)[C:4]=12)=[O:20]

Participants

4

Reactant 2

HCID 5234Sodium ChlorideHCID 101526Moxifloxacin hydrochloride

Product 1

HCID 152946Moxifloxacin

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
121 °C

Procedure

The water is initially charged in a reaction vessel made of glass, and moxifloxacin hydrochloride is dissolved therein with stirring. Sodium chloride is added to the solution of the active compound and dissolved therein. An Fe(III) chloride solution is added to the mixture. The mixture is filtered through a 0.2 μm sterile filter and in each case 250 ml are filled into an infusion bottle which is closed and heated in an autoclave at 121° C. for 20 min.

Workup

  1. dissolutionis dissolved
  2. dissolutiondissolved
  3. filtrationThe mixture is filtered through a 0.2 μm
  4. filtrationsterile filter and in each case 250 ml
  5. additionare filled into an infusion bottle which
  6. customis closed

Sources & evidence

ORD record
ord-537fac695b5f47cd9788065522379c4b
Source dataset
uspto-grants-2003_04
Patent number
US06548079B1

Reaction notes

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