Sodium Chloride → Moxifloxacin

HRID 1265945Notes

Reaction equation

HRID 1265945 reaction equation
[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:17][C@@H:16]3[C@@H:11]([CH2:12][CH2:13][CH2:14][NH:15]3)[CH2:10]2)=[C:7]([F:18])[CH:6]=[C:5]2[C:19]([C:21]([C:27]([OH:29])=[O:28])=[CH:22][N:23]([CH:24]3[CH2:26][CH2:25]3)[C:4]=12)=[O:20].Cl.[Cl-].[Na+]>O>[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:17][C@@H:16]3[C@@H:11]([CH2:12][CH2:13][CH2:14][NH:15]3)[CH2:10]2)=[C:7]([F:18])[CH:6]=[C:5]2[C:19]([C:21]([C:27]([OH:29])=[O:28])=[CH:22][N:23]([CH:24]3[CH2:26][CH2:25]3)[C:4]=12)=[O:20]

Participants

4

Reactant 2

HCID 5234Sodium ChlorideHCID 101526Moxifloxacin hydrochloride

Product 1

HCID 152946Moxifloxacin

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
121 °C

Procedure

The water is initially charged in a reaction vessel made of stainless steel of pharmaceutical quality, and moxifloxacin hydrochloride is dissolved therein with stirring. Sodium chloride is added to the solution of the active compound and dissolved therein. The mixture is filtered through a 0.2 μm sterile filter and in each case 100 ml is filled into an infusion bottle which is closed and heated in an autoclave at 121° C. for 20 min.

Workup

  1. dissolutionis dissolved
  2. dissolutiondissolved
  3. filtrationThe mixture is filtered through a 0.2 μm
  4. filtrationsterile filter and in each case 100 ml
  5. additionis filled into an infusion bottle which
  6. customis closed

Sources & evidence

ORD record
ord-cdbc8b3480fe4fe791b6871605810b42
Source dataset
uspto-grants-2003_04
Patent number
US06548079B1

Reaction notes

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