Methylamine → HCID 70008308, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described in Example 32 from aldehyde 97a and methylamine (2M/MeOH) to give 0.069 g (42%) of a white solid: mp=204-208° C. (dec); Rf=0.03 (7% methanolic ammonia/CHCl3); IR (KBr) 1655, 1609, 1470, 1437 cm−1; 1H NMR (DMSO-d6) δ 2.30 (s, 3H), 3.54-3.55 (m, 2H), 3.75 (s, 2H), 4.45-4.46 (m, 2H), 7.52 (d, 2H, J=8.2 Hz), 7.57-7.61 (m, 1H), 7.73-7.76 (m, 1H), 7.80 (d, 2H, J=8.2 Hz), 8.59-8.63 (m, 1H). HRMS calcd for C18H17N4OF 324.1386 (M+), found 324.1378. Anal. (C18H17N4OF.0.3H2O) C, H, N.

Provenance & Evidence