Dimethylamine → HCID 70006868, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described in Example 32 from aldehyde 97a and dimethylamine (2M/MeOH) to give 0.10 g (60%) of a white solid: mp=240° C. (dec); Rf=0.08 (7% methanolic ammonia/CHCl3); IR (KBr) 1669, 1607, 1487, 1458 cm−1; 1H NMR (DMSO-d6) δ 2.20 (s, 6H), 3.51 (s, 2H), 3.54-3.55 (m, 2H), 4.45-4.47 (m, 2H), 7.50 (d, 2H, J=8.2 Hz), 7.57-7.61 (m, 1H), 7.73-7.76 (m, 1H), 7.82 (d, 2H, J=8.2 Hz), 8.59-8.63 (m, 1H). HRMS calcd for C19H19N4OF 338.1543 (M+), found 338.1558. Anal. (C19H19N4OF0.2H2O) C, H, N. found 412.2124. Anal. (C25H25N5O.0.5 H2O, 3.5 TFA) C, H, N.

Provenance & Evidence