9-Nitro-1,2,3,4-tetrahydro-5H-1,4-benzodiazepin-5-one → HCID 18548553, compound

HRID 1266042Notes

Reaction equation

HRID 1266042 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[C:6]([N+:11]([O-:13])=[O:12])[C:5]=1Br.[N+:16]([C:19]1[C:24]2[NH:25]CCNC(=O)C=2C=CC=1)([O-])=O>>[F:10][C:8]1[CH:7]=[C:6]([N+:11]([O-:13])=[O:12])[C:5]2[NH:16][CH2:19][CH2:24][NH:25][C:3](=[O:15])[C:4]=2[CH:9]=1

Participants

3

Reactant 2

HCID 27716119-Nitro-1,2,3,4-tetrahydro-5H-1,4-benzodiazepin-5-oneHCID 20577071HCID 20577071, compound

Product 1

HCID 18548553HCID 18548553, compound

Procedure

This compound was prepared from 2-bromo-5-fluoro-3-nitro-benzoic acid methyl ester according to the procedure described in Example 2 for the intermediate f. Obtained 2.20 g (68%).

Workup

  1. customObtained 2.20 g (68%)

Sources & evidence

ORD record
ord-1e6646c1743a434785b2f2e3408a53f0
Source dataset
uspto-grants-2003_04
Patent number
US06548494B1

Reaction notes

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