N,N-Dimethyl-1,4-cyclohexanediamine → HCID 9887659, compound

Participants

Reaction Steps

A solution of 2-chloro-6,7-dimethoxy-3-pyridin-2-yl-quinoxaline (0.91 g) and N,N-dimethyl-cyclohexane-1,4-diamine (0.86 g) in toluene (30 mL) was refluxed under nitrogen atmosphere for 16 hours. The reaction mixture was cooled, filtered, and concentrated under vacuum. The residue was purified by flash chromatography (silica gel, 1:9 methanol/dichloromethane) to give a yellow solid. This solid was recrystallized in ethyl acetate/hexane to give the product as yellow crystals (0.92 g); mp 168-171° C.

Provenance & Evidence