反应详情

A solution of 2-chloro-3-pyridin-2-yl-7,8-dihydro-6H-cyclopenta[g]quinoxaline (0.5 g) and N,N-dimethyl-cyclohexane-1,4-diamine (0.51 g) in toluene (30 mL) was refluxed under nitrogen atmosphere for 16 hours. The reaction was cooled, filtered, and concentrated under vacuum. The residue was purified by flash chromatography (silica gel, 1:19 methanol/dichloromethane) to give a yellow solid. Recrystallization from methanol and water gave the product as yellow crystals ( 0.3 g); mp 158-161° C.

1. temperatureThe reaction was cooled
2. filtrationfiltered
3. concentrationconcentrated under vacuum
4. customThe residue was purified by flash chromatography (silica gel, 1:19 methanol/dichloromethane)
5. customto give a yellow solid
6. customRecrystallization from methanol and water