反应详情

A solution of 2,6,7-trichloro-3-pyridin-2-yl-quinoxaline (0.50 g) and N,N-dimethyl-ethane-1,2-diamine (0.28 g) in toluene (20 mL) was refluxed under nitrogen atmosphere for 16 hours. After refluxing, the reaction mixture was cooled, filtered, and concentrated under vacuum. The residue was purified by flash chromatography (silica gel, 1:9 methanol/dichloromethane) to give the product as a yellow solid (0.26 g); mp 95-97° C.

1. temperatureAfter refluxing
2. temperaturethe reaction mixture was cooled
3. filtrationfiltered
4. concentrationconcentrated under vacuum
5. customThe residue was purified by flash chromatography (silica gel, 1:9 methanol/dichloromethane)