Choline, hydroxide → HCID 18549169, compound

Participants

Reaction Steps

Choline 7-fluoro-8-[4-(4-fluoroanilino)piperidino]-1-methyl-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylate was prepared under the conditions of Example 1, but from 1.6 g of 7-fluoro-8-[4-(4-fluoroanilino)piperidino]-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid in 16 cm3 of methanol and 1.3 cm3 of a 45% solution of choline hydroxide in methanol. After recrystallizing twice from 25 cm3 of 2-propanol on each occasion, 1.1 g of choline 7-fluoro-8-[4-(4-fluoroanilino)piperidino]-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylate were obtained in the form of a yellow solid melting at about 200-205° C.

Provenance & Evidence