HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 6-{3-[4-(4-fluorobenzyl)piperid-1-yl]propyl}-3H-benzoxazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-(3-chloropropyl)-2(3H)-Benzoxazolone | HCID 11063738 | — |
| Reactant | 4-[(4-Fluorophenyl)methyl]piperidine hydrochloride | HCID 17039492 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-{3-[4-(4-fluorobenzyl)piperid-1-yl]propyl}-3H-benzoxazol-2-one | HCID 9799414 | 93% |
Reaction Steps
A suspension of 5.5 g of 6-(3-chloropropyl)-3H-benzoxazol-2-one in 50 ml of ethanol is admixed with 5.7 g of 4-(4-fluorobenzyl)piperidine hydrochloride and 7.2 ml of triethylamine. The mixture is stirred under reflux for one hour and subjected to customary workup to give 8.5 g of 6-{3-[4-(4-fluorobenzyl)piperid-1-yl]propyl}-3H-benzoxazol-2-one, m.p. 105-107°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06548516B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-7e66bd83618c47ec84d4ca2ddb4de1d4 |
| Source note | uspto-grants-2003_04 |