HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuryl chloride → 2-{2,5-bis(trifluoromethyl)phenyl}amino-5-chloro-3-cyclohexyl-6-trifluoromethyl-4(3H)-pyrimidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | 2-{2,5-bis(trifluoromethyl)phenyl}amino-3-cyclohexyl-6-trifluoromethyl-4(3H)-pyrimidinone | HCID 18549228 | — |
| Product | 2-{2,5-bis(trifluoromethyl)phenyl}amino-5-chloro-3-cyclohexyl-6-trifluoromethyl-4(3H)-pyrimidinone | HCID 18549230 | 93% |
Reaction Steps
In accordance with the method of Example 25, chlorination of 2-{2,5-bis(trifluoromethyl)phenyl}amino-3-cyclohexyl-6-trifluoromethyl-4(3H)-pyrimidinone (80 mg, 0.18 mmol) was carried out using sulfuryl chloride to obtain white solid of 2-{2,5-bis(trifluoromethyl)phenyl}amino-5-chloro-3-cyclohexyl-6-trifluoromethyl-4(3H)-pyrimidinone [Compound No. 65].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06548511B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-97993bd5b1574f82ba060ee4a01b59a7 |
| Source note | uspto-grants-2003_04 |