4,4,4-Trifluorobutylamine → 2,2-Diphenyl-N-(4,4,4-trifluoro-butyl)-propionamide

HRID 1266241Notes

Reaction equation

HRID 1266241 reaction equation
[C:1]1([C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)([CH3:11])[C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:18][C:19]([F:25])([F:24])[CH2:20][CH2:21][CH2:22][NH2:23]>>[C:1]1([C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)([CH3:11])[C:8]([NH:23][CH2:22][CH2:21][CH2:20][C:19]([F:25])([F:24])[F:18])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 1366454,4,4-TrifluorobutylamineHCID 114479422,2-diphenylpropanoyl Chloride

Product 1

HCID 185496872,2-Diphenyl-N-(4,4,4-trifluoro-butyl)-propionamide

Procedure

The title compound, white solid, m.p. 82° C. and MS: m/e=336.2 (M+H+) was prepared in accordance with the general method of example 1 from 2,2-diphenylpropionyl chloride and 4,4,4-trifluorobutyl-amine.

Sources & evidence

ORD record
ord-619998c596b64945a2e3602993a42857
Source dataset
uspto-grants-2003_04
Patent number
US06548522B1

Reaction notes

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